https://doi.org/10.31288/oftalmolzh201445965

Analysis of «lag time» in the diagnosis of retinoblastoma in Ukraine

Bobrova N. F., Sorochinskaya N. A., Tronina S. A., Dembovetskaya A. N., Sukhodoeva L. A., Levitskiy I. M., Trofimova N. B.

State Institution The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine, Odessa, (Ukraine)

Introduction. Early diagnosis of oncological diseases, particularly eye tumors, in a great measure determines the success of treatment, as well the prognosis for af­fected organ and patient's life preservation.

Aim. Analysis of «lag time» in the diagnosis of retinoblastoma in Ukraine. Materials and Methods. The paper presents the results of a retrospective analysis of medical records of223 children with retinoblastoma (296 eyes) were treated at the Pediatric Ophthalmopathology Department of SI «The Filatov Institute of Eye Diseases and Tissue Therapy of NAMS of Ukraine» in the period from 1996 till 2004 and from 2009 till 2013. The first symptoms of the disease, which were the reason of visit to a doctor and symptoms at the initial examination at the special­ized department, interval between first symptoms fixation by parents and primary doctor's examination (primary lag time) and term from initial application until the final diagnosis (secondary lag time) have been analysed.

Results. Leykokoria and strabismus were the most common symptoms noted by parents first. The positive dynamics of rates with primary and secondary lag time duration reduction in recent years was revealed.

Conclusions. The retrospective analysis have shown the important role of parents' attention to the health of their child in the problem of early diagnosis of retinoblas-toma.

The ways of pediatric ophthalmic oncology service for children with retinoblastoma improvement consist in organization of effective preventive examinations of children, especially of younger age group, wide parents informing about the retinoblastoma symptoms and their early detection methods, improvement of profes-sional skills of primary care physicians — pediatricians, neonatologists, district ophthalmologists regarding diagnosis of this pathology.

Key words: retinoblastoma, early diagnostic, lag time  

References

1.     Saakyan SV. Modern aprouch to retinoblastoma treatment/ Russian Ophthalmol. Jurn. 2008;1:33-8. Rus­sian.

2.     Bonanomi MT, Almeida MT, Cristofani LM et al. Retino-blastoma: a three-year-study at a Brazilian medical school hospital. Clinics. 2009;64(5):427- 34.
Crossref

3.     Bowman RJ, Mafwiri M, Luthert P et al. Outcome of retinoblastoma in east Africa. Pediatr. Blood Cancer.2008;1(50):160-2.
Crossref

4.     Chantada GL, Luna-Fineman S, Quaddoumi I et al. Retinoblastoma in developing countries. Retinoblastoma. Springer Science+Business Media, LLC 2010. New York, NY 10013, USA.133-41.
Crossref

5.     Chantada GL. Retinoblastoma: Lessons and challenges from developing countries. Ellsworth Lecture 2011. Oph­thalmic Genetics, 2011; 32(4): 196- 203.
Crossref

6.     Goddard AG, Kingston JE, Hungerford JL. Delayed in di­agnosis of retinoblastoma: risk factors and treatment out­come. Br. J Ophthalmol. 1999;83:1320-3.
Crossref

7.     Kaimbo WK, Mvitu MM, Missotten L. Presenting signs of retinoblastoma in Congolese patients. Bull Soc. Belge Ophthalmol. 2002;283:37-41.

8.     Lukusa AK, Aloni MN, Kadima-Tshimanga B et al. Retinoblastoma in the Democratic Republic of Congo: 20-Year Review from a Tertiary Hospital in Kinshasa. Jornal of Cancer Epidemiology.

9.     Ramirez-Ortiz MA, Ponce-Castaneda MV, Cabrera-Munoz ML et al. Diagnostic delay and socio-demographic predictors of stage at diagnosis and mortality in unilateral and bilateral retinoblastoma. Cancer Epidemiology Biomarkers Prev. 2014;23(5).
Crossref

10.  Rodrigues KES, Latorre MR, Camargo B. Delayed diagnosis in retinoblastoma. Jornal de Pediatria. 2004;80;6.
Crossref

11.  Rodriguez-Galindo C, Mathew W Wilson, Guillermo Chantada et al. Retinoblastoma: One World, One Vision.Pediatrics. ;122(3).
Crossref

12.  Palazzi MA, Stephan C, Brandalise SR et al. Retinoblastoma Diagnosis: A Proposal Based on the Experience of Centro Infantil Boldrini, Brazil. Pediatric Hematology and Oncology. 2013;30:379-85.
Crossref

13.  Saiju R, Moore G, Shrestha U et al. Retinoblastoma: geo­graphic distribution and presentation at a tertiary eye care centre in Kathmandu, Nepal. Nepal J. Ophthalmol 2013; 5(10):169-76.
Crossref