http://doi.org/10.31288/oftalmolzh201034346

ULTRASTRUCTURAL CHANGES IN THE NERVOUS STRUCTURES OF THE RETINAL GANGLIONIC LAYER OF RATS IN THE DYNAMICS AFTER METHANOL INFLUENCE

N. I. Molchanyuk, N. E. Dumbrova

Odessa, Ukraine

Changes in the ganglionic cells (GC) and processes of the Mullerian cells (PMUC) of the retinal ganglionic layer of rats were studied photo-optically and electron-microscopically in the dynamics (1—14 days) in response to the single introduction of methanol in the dose of 0.75 g/kg of the body mass.

It is revealed that in response to the toxic effect of methanol in GC the increase of destructive changes in the intracellular structures in dynamics was observed. In PMUC there were also manifested unidirectional changes but they were expressed to a considerably lesser degree. It is necessary to emphasize that already in the early period (first 24 hrs) significant phenomena of the alteration of the ultrastructures in the small GC were noted, which were also characteristic of PMUC. For obtaining more complete ideas about the nature of changes in the nervous structures of the eye under the effect of methanol the experiment will be continued.

 

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