Oftalmol Zh.2010;6:52-55.
http://doi.org/10.31288/oftalmolzh201065255
INFLUENCE OF ALLERGIC UVEITIS ON INDICES OF LIPID PEROXIDATION OF THE CHAMBER HUMOR IN EXPERIMENTAL GLAUCOMA
Savko V. V., Khelifi Amani Bent Ayachi, Parkhomenko T. V.
Odessa, Ukraine
The paper presents the study of the influence of allergic uveitis on the indices of lipid peroxidation in the chamber humor in experimental glaucoma.
The experimental studies were conducted on 31 rabbit, which were modeled allergic uveitis against the background of experimental glaucoma.
It is shown that development of the inflammatory process in the uveal tract in animals with experimental glaucoma leads to a sharp increase in the content of both intermediate and final products of POL in the chamber humor.
References
1.Курышева Н. И., Винецкая М. И., Еричев В. П. Роль свободнорадикальных реакций камерной влаги в развитии первичной открытоугольной глаукомы // Вестн. офтальмол. - 1996. - № 4. - C. 3-5.
2.Луценко Н. С. Гормонально-метаболические нарушения при первичной открытоугольной глаукоме и патогенетическое обоснование их коррекции в ком-плексном лечении: автореф. дис. канд. мед.наук : 14.01.18. - Запорожье. - 2007. - 18 с.
3.Наследов А. SPSS компьютерный анализ данных в психологии и социальных науках. // Спб.: Питер, 2005. - 416 с.
4.Смалюх Н. В. Экспериментальное изучение эффективности фонореза фторафура при моделированном аллергическом увеите / Н. В. Смалюх // Офтальмоло¬гический журнал. - 1983. - № 7. - C. 397-399.
5.Equi R. A., Jumper M., Cha C. Hyaluronal polymer size modulates intraocular pressure / J Ocul. Pharmacol. Ther. - 1997. - V. 13. - № 4. - P. 289-295.
6.Epstein D. L., Kater A. W. Influences of glutathione and sulfhydryl containing compounds on aqueous humor outflow function / Exp, Eye Res. - 1990. - V. 50. - P. 785¬793.
7.Izzotti A., Saccа S. C., Cartiglia C. Oxidative deoxyribo-nucleic acid damage in the eyes of glaucoma patients / Am j Med. - 2003. - V. 114. - P. 638- 646.
8.Liu K. M., Swann D. Inhibition of oxidative degradation of hyaluronic acid by uric acid / Curr. Eye Res. - 1984. -V. 3. - P. 1049-1053.
9.Kumar D. M., Agarwal N. Oxidative stress in glaucoma: a burden of evidence / J Glaucoma. — 2007. — V. 16. — P. 334- 343.
10.Lieven C. J., Vrabec J. P., Levin L. A. The effect of oxidative stress on mitochondrial transmembrane potential in retinal ganglion cells / Antioxid. Redox. Signal. — 2003. — V. 5. — № 5. — P. 641- 646.
11.Maher P., Hanneken A. Flavonoids protect retinal ganglion cells from oxidative stress-induced death / Invest. Ophthalmol. Vis. Sci. — 2005. — V. 46. — P. 4796- 4803.
12.Maher P., Hanneken A. The molecular basis of oxidative stress-induced cell death in an immortalized retinal ganglion cell line / Invest. Ophthalmol. Vis. Sci. — 2005. — V. 46. — P. 749-757.
13.Moraczewski A. L., Lee R. K., Palmberg P. F. et al. Outcomes of treatment of neovascular glaucoma with intravitreal bevacizumab / Br J Ophthalmol. — 2009. — V. 93. — P. 589-593.
14.Moreno M. C., Marcos H. A. A new experimental model of glaucoma in rats through intracameral injection of hyaluronic acid / Exp. Eye Res. — 2005.
15.Moreno M. C., Campanelli J. L., Sande P. Retinal oxidative stress induced by high intraocular pressure / Free Radic. Biol. Med. — 2004. — V. 37. — P. 803- 812.
16.Moreno M. C., Croxatto J. O., Campanelli J. L. Retinal damage-after the chronic injection of hyaluronic acid in the rat anterior chamber / Invest. Ophthalmol. Vis. Sci. — 2002. — V. 43. — P. 2158.
17.Sacca S. C., Pascotto A., Camicione O. Oxidative DNA damage in human trabecular meshwork / Arch. Ophthalmol. — 2005. — V. 123. — P. 458- 463.
18.Schori H. Vaccination for protection of retinal ganglion cells against death from glutamate cytotoxicity and ocular hypertension: implications for glaucoma / PNAS. — 2001. — V. 98. — № 6. — P. 3398- 3403.
19.Tezel G., Yang X, Cai J. Proteomic identification of oxi-datively modified retinal proteins in a chronic pressure-induced ret model of glaucoma / Invest. Ophthalmol. Vis. Sci. — 2005. — V. 46. — P. 3177-3187.