https://doi.org/10.31288/oftalmolzh201466671

Experimental presuppositions for correction the glutathione level in the tissue of the mucous membrane and lacrimal fluid in acute conjunctivitis in conditions of hyperglycemia

Drozhzhina G. I. 1, Zhmud T. M. 2,

1State Institution The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine; Odessa, (Ukraine)

2Vinnitsa National Medical University named after Pirogov; Vinnitsa (Ukraine)

Introduction. Research on the problems of pathological conditions of the surface tissues of the eye is of particular relevance.

Purpose. Examine the level of glutathione in the mucosal tissue of the conjunctiva and lacrimal fluid in experimental conjunctivitis in terms of developing diabetes. Material and methods. For the experiment used 54 rabbits, which were divided into 3 groups: Group 1 — control group (8 animals), Group 2 — experimental ani¬mals with developing conjunctivitis (23 rabbits), group 3 — experimental animals with conjunctivitis in terms of developing diabetes (21 rabbit). To investigate the tissue taken conjunctiva and lacrimal fluid in which a determination is made of reduced glutathione.

Results. With the development of experimental conjunctivitis and streptozotocin diabetes marked lowering of reduced glutathione in the tissue of the conjunctiva and lacrimal fluid.

Conclusions. 1. With the development of inflammation in the conjunctiva in a simulation of streptozotocin diabetes says a sharp decrease in the levels of glutathione compared with the data when conjunctivitis is caused in animals without diabetes. Under these conditions, the level of glutathione decreased by 17.0 %, 18.0 % and 29.4 % in different periods of observation. 2. In the simulation streptozotocin diaetes in animals with conjunctivitis largely reduces the secretion of glutathione in the lacrimal fluid than in the group with conjunctivitis without diabetes. Thus, inthe first term of the reduction was — 13.6 %, in the second period — 18 % and in the third term — 21.8 %. 

Key words: acute conjunctivitis, hyperglycemia, glutathione levels, correction

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