Oftalmol Zh.2009;4:71-80.
http://doi.org/10.31288/oftalmolzh200947180
AGE CHANGES OF THE CONREAL ENDOTHELIUM AS REFLECTION OF UNIVERSAL MECHANISM OF AGING
A. V. Artemov
Odessa, Ukraine
Laws of aging unknown earlier were theoretically substantiated and practically confirmed by the example of the corneal endothelium, consisting of the fact that age reduction in the functional and adaptive possibilities of the tissues, organs and organism on the whole that is considered one of the main manifestations of the process indicated, is the consequence of the gradual and uniform decrease of the number of cells without preliminary damage, disease or any other pathologic change in the cells themselves. Thus, aging is a unique pathologic process, characteristic only of cellular associations, which form the tissue, but not peculiar to unicellular organisms and to the separate cells, which form part of the tissues. Aging of the organism occurs without aging of the cells.
References
1.Артемов А. В. Донорская роговицы в аспекте современной патологии. — Одесса: Интерпринт, 2007. — 186 с.
2.Борзенок С. А. Медико-технологические и методоло-гические основы эффективной деятельности глазных тканевых банков России в обеспечении операций по сквозной трансплантации роговицы // Автореф. дис. ... докт. мед. наук. — М., 2008. — 50 с.
3.Вит В. В. Строение зрительной системы человека. — Одесса: Астропринт, 2003. — 664 с.
4.Давыдовский И. В. Геронтология. — М.: Медицина, 1966. — 300 с.
5.Запорожан В. Н., Бажора Ю. И. Стволовые клетки. — Одесса: Одес. держ. мед. ун-т., 2004. — 228 с.
6.Фильченков А. А., Стойка Р. С. Апоптоз и рак. — Киев: Морион, 1999. — 184 с.
7.Фролькис В. В. Старение и увеличение продолжительности жизни. — Л.: Наука, 1988. — 239 с.
8.Hoffher K. J. Corneal decompensation after corneal en-dothelium count // Amer. J. Ophthalmol. — 1979. — Vol. 87. — P. 252-253.
9.Mishima S. Clinical investigation of the corneal endothelium // Amer. J. Ophthalmol. — 1982. — Vol. 93. — P. 129.
10.Muller-Pedersen T. A comparative study of human corneal keratocyte and endothelial cell density during ageing // Cornea. — 1997. — Vol. 16. — P. 333-338.
11.Musch D. C., Meyer R. F., Sugar A. Predictive factors for endothelial cell loss after penetrating keratoplasty // Arch. Ophthalmol. — 1993. — Vol. 101. — P. 80-93.
12.Murphy C., Alvarado J., Jester R., Maglio M. Prenatal and postnatal cellularity of the human corneal endothelium: a quantitative histologic study // Invest. Ophthalmol. Vis. Sci. — 1984. — Vol. 25. — P. 312-332.
13.Probst L. E., Halfaker J. S., Holland E. J. Quality of corneal donor tissue in the greather-than-75-year age group // Cornea. — 1997. — Vol. 16. — P. 507-511.
14.Sherraed E., Novakovic P., Speedwell L. Age-related changes of the corneal endothelium and stroma as seen in vivo by specular microscopy // Eye. — 1987. — Vol. 1. — P. 197-208.
15.Stent G., Calendar R. Molecular genetics. An introductory narrative. Philad., 1979. Русский перевод: Молекулярная генетика. Изд-во «Мир», М., 1981. — 646 с.
16.Vasara K., Setala K., Ruusuvaara P. Follow-up study of human corneal endothelial cells, photographed in vitro before enucleation and 20 years leter in grafts // Acta Oph-thalmol. Scandinavica. — 1999. — Vol. 77. — P. 273-276.