J.ophthalmol.(Ukraine).2016;6:57-64.

https://doi.org/10.31288/oftalmolzh201765764

Responses of the rabbit’s soft tissue of the orbit and periorbital area, and orbital bone structures to the introduction of the polymer composition implant and PFTE implant

N.M. Bigun1, V.V. Vit2, A.P. Maletskiy2, V.I. Dubkova3

1Lviv Regional Clinical Hospital, Ukraine

2Filatov Institute of Eye Disease, Odesa, Ukraine

3MEDBIOTECH LLC, Minsk, Republic of Belarus

E-mail: maletskiy@filatov.com.ua           

Background: The synthetic polymer materials to be used in plastic and reconstructive surgery for craniofacial injuries should have high compatibility with biological tissues. In cooperation with MEDBIOTECH LLC (Republic of Belarus), we have developed a carbon-polymer composite with thermo- and electrophysical characteristics close to those of viable biological tissues.

Purpose: To investigate experimentally the responses of the soft tissue of the orbit and periorbital area, and orbital bones to the polymer composite implants (PCI) and polytetrafluoroethylene (PFTE) implants.

Materials and Methods: Chinchilla rabbits received one of the two types of implants, PCI (Mt, Mt1, Mt2 or Mt2+ ceftriaxone versions), or PFTE implants, into the periorbital area, scleral sac, orbital tissue, or auricle tissue. The response of the soft tissues and bone structures to the implants was assessed based on changes in clinical and pathomorphological indices at days 10, 30 and 60.

Results: In any type of implant, post-surgical wound healing was found to occur by primary intention. Inflammatory responses of the rabbit’s soft tissue of the orbit and periorbital area, and of the orbital bones to the PFTE implant were more pronounced than those to the PCI. We found histomorphologically that adjacent soft tissues grew into the PCI, and a capsule formed around the PFTE implant.

Conclusion: The polymer composite implants were found to have improved biocompatibility compared to polytetrafluoroethylene implants.

Keywords: periorbital area, scleral sac, auricle tissue, reconstructive surgery, polymer composite, polytetrafluoroethylene, experiment         

References

  1. Anina IeI, Levtiukh VI. [Surgical and therapeutic restoration of vision]. In: [Proceedings of the twelfth symposium in ophthalmology]. June 29 – July 1, 2001, Chernivtsi, Ukraine. p.8. Ukrainian
  2. Veselovska ZF, Shadrina NM, Veselovska ZF. [Efficacy of the new technology for forming a locomotive stump with the use of combination implant]. Oftalmol Zh. 2004; 3:32-35. Ukrainian
  3. Grusha IaO, Khossein PKh, Novikov IA. [Use of Karbotekstim-M in orbital wall reconstruction with allocartilage or alloplant]. Oftalmologiya. 2004;4:30-33. Russian
  4. Gundorova RA, Verigo EN, Chernookova VA. [Indications for globe removal based on the analysis of the course of post-traumatic uveitis]. In: [Proceedings of the Conference on Inflammatory Ocular Disorders]. June 18 – 19, 2004, Chelyabinsk, Russia. pp.95-98.
  5. Kaniukov VN, Stadnikov AA, Trubina OM, Gorbunov AA. [Comprehensive development of biological transplants for eye surgery]. In: [Proceedings of the Conference on Surgical Management and Rehabilitation of Patients with Ocular Disorders]. October 7-9, 2004, Kyiv, Ukraine. pp 135-137. Russian
  6. Krasnovid TA, Tychina NP, Narovchenko TN. [On the main causes of globe removal]. In: [Proceedings of the 2nd Congress of Black Sea Ophthalmological Society]. September 8-10, 2004, Odesa, Ukraine. pp 147-148. Russian
  7. Sergiienko NM, Rykov SA, Kryzhanovskaia TV. [State and changes in prevalence of blindness and visual disability after visual disorders in Ukraine]. Collection of papers from researchers of the Shupik Kyiv Medical Academy of Postgraduate Education. 2004; 14(4): 582–586. Russian
  8. Fyodorov AA, Grusha IaO, Khossein PKh. [Features of the tissue response to synthetic materials used in the surgery of the orbit]. In: [Proceedings of the 2nd Congress of Black Sea Ophthalmological Society]. September 8-10, 2004, Odesa, Ukraine. p 212. Russian
  9. Filatova IA, Poliakova LIa. [Causes of and methods for removing the globe according to the Department of Ocular Trauma, Helmholtz Institute]. In: [Collection of papers “Rehabilitation after very severe emergency-related eye injuries”]. Moscow, 2002. pp. 44-46. Russian
  10. Iakhnitskaia LK, Krasilnikova VL, Kovalenko IuD. [Enucleation in current ophthalmology]. Zdravookhranenie Belorussii. 2001; 12:37-38. Russian
  11. Custer PL. Postoperative rotation of hydroxyapatite enucleation implants. Arch Ophthalmol. 1999 Nov;117(11):1521-3