https://doi.org/10.31288/oftalmolzh201832731

Changes in corneal scleral rigidity and corneal thickness at various target intraocular pressures in patients with stabilized primary open-angle glaucoma 

Peretyagin O.A., Cand. Med. Sc., Ass. Prof.; Dmitriev S.K., Dr. Med. Sc., Prof.; Lazar Yu.M., Cand. Med. Sc.; Tatarina Yu.A., Junior Research Fellow

SI “Filatov Institute of Eye Diseases and Tissue Therapy of NAMS of Ukraine”;

Odessa (Ukraine)

E-mail: tatarina.j.a@gmail.com               

TO CITE THIS ARTICLE: Peretyagin OA, Dmitriev SK, Lazar YuM, Tatarina YuA. Changes in corneal scleral rigidity and corneal thickness at various target intraocular pressures in patients with stabilized primary open-angle glaucoma.  J.ophthalmol.(Ukraine).2018;3:27-31. https://doi.org/10.31288/oftalmolzh201832731

 

Introduction. Current methods for determining target IOP have disadvantages. Investigation of data on corneoscleral rigidity and corneal thickness in patients with stabilized primary open-angle glaucoma of stages I-II may improve the method of determining target IOP.

Purpose. To study the correlation between indices of corneoscleral rigidity, corneal thickness and target IOP in patients with stabilized primary open-angle glaucoma  (POAG) of stages I-II.

Material and Methods. 30 patients (30 eyes) with stabilized POAG of the І-ІІ stage were examined. The patients underwent pachymetry, applanation tonometry, dynamic contour tonometry, corneal rigidity determination and tonography. The progression of glaucoma was monitored by the HFA II Central 30-2 Threshold Test and SOCT Copernicus + units. Target IOP was calculated taking into account the age and the level of diastolic blood pressure.

Results. It was found that, in group 1 with target IOP of 6.2 -13.9 mm Hg, the corneal thickness was 540-590 μm and rigidity of the cornea ranged from 1.0 to 4.0 mm Hg; while in group 2 with target IOP of 14.0 -16.8 mm Hg, the corneal thickness was 510-570 μm and rigidity of the cornea ranged from -3.0 to 1.5 mm Hg.

Conclusions. It was found that the lower a value of achieved target IOP, the higher corneal rigidity in patients with stabilized stage I-II POAG.

Keywords: target intraocular pressure, primary open-angle glaucoma, corneal thickness, corneal rigidity

References

1.Vodovozov AM. [Tolerant and intolerant intraocular pressure in glaucoma]. Volgograd; 1991. 160p. In Russian. 

2.Fokin VP, Balanin SV. [Determination of target intraocular pressure in patients with primary open-angle glaucoma] Glaukoma. 2007;6(4):16-9. In Russian. 

3.Boriskina LN, Balanin SV, Makovkin EM. [Corneoscleral rigidity as a cumulative biometric parameter]. Vestnik OGU. 4(153):48-50. In Russian.  

4.Svetlova OV, Koshits IN. [Physiological functions of fibrous  tunic of eye and their operative mechanisms. Normal and pathological physiology of eye. Textbook]. SPb: Izdatelstvo GBOU VPO SZGMU im. I.I. Mechnikova; 2013. 71p. In Russian. 

5.Svetlova OV. [Functional characteristics of interaction of the sclera, accommodation and drainage systems of the eye in glaucomatous and myopic pathology]. Author’s thesis for Dr. Med. Sc. Moscow; 2010:24-7. In Russian.  

6.Ehlers N, Bramsen T, Sperling S. Applanation tonometry and central corneal thickness. Acta Ophtalmol. (Copenh). 1975;53:34-43. 
Crossref   Pubmed

7.Liu J, Roberts CJ. Influence of corneal biomechanical properties on intraocular  pressure measurement: quantitative analysis. J. Cataract. Refract. Surg. 2006;32(7):1073-6.

8.Kaufmann C, Bachmann LM, Thiel MA. Comparison of dynamic contour tonometry with Goldmann applanation tonometry. Invest Ophthalmol Vis Sci. 2004;45:318-21.
Crossref   Pubmed

9.Gontijo L. Corneal rigidity in numbers http://escrs.conference2web.com/content/4496// 27th Congress of the ESCRS : – Barcelona, – 2009.

10.Glantz S. [Medical and biological statistics. Translated from English by Danilov YuA]. M.:Praktika;1999.459p. In Russian. 

11.Lapach SN, Chubenko AV, Babich PN. [Statistical methods in medical and biological investigations using Excel]. K.:Morion LTD; 2000. 320p. In Russian.