J.ophthalmol.(Ukraine).2022;6:14-18.
http://doi.org/10.31288/oftalmolzh202261418
Received: 02.07.2022; Accepted: 05.12.2022; Published on-line: 21.12.2022
Assessing factors of endothelial vascular dysfunction in patients with primary open-angle glaucoma
A. M. Dusmukhamedova 1, D. M. Tuychibaeva 1, A. A. Khadzhimetov 2
1 Tashkent State Dentistry Institute
2 Soglonkuz Clinic
Tashkent (Uzbekistan)
TO CITE THIS ARTICLE: Dusmukhamedova AM, Tuychibaeva DM, Khadzhimetov AA. Assessing factors of endothelial vascular dysfunction in patients with primary open-angle glaucoma. J.ophthalmol.(Ukraine).2022;6:14-18. http://doi.org/10.31288/oftalmolzh202261418
Background: Glaucoma is a leading cause of visual disability and irreversible blindness worldwide, and significantly affects quality of life. An improvement in the early diagnosis and prevention of primary glaucoma has a special value due to increasing social significance of the disease.
Purpose: To investigate the value of the factors affecting vascular endothelium (oxidative stress, complement components and blood lipid profile) in patients with primary open-angle glaucoma (POAG).
Material and Methods: Ninety two patients (age, 65 to 80 years) with POAG and 30 controls (somatically healthy individuals of a similar age and no known eye disease) were included in the study. They underwent an eye examination including visual acuity, Maklakoff tonometry, non-contact tonometry, biomicroscopy, gonioscopy, and pachymetry. Plasma lipid peroxidation and antioxidant activity levels, blood lipid composition and blood C3 and C5a levels were assessed.
Results: Blood malondialdehyde (MDA) levels in patients with POAG were 87% higher compared to controls. Blood C3 levels in patients with POAG were 18% higher compared to controls. The C5a complement is a multicomponent plasma enzyme system that exhibits lysis and opsonization functions during activation. Blood C5a levels were 6 times higher in patients with POAG than in controls (13.86 ± 0.44 mg/scale division versus 2.33 ± 0.11 mg/scale division).
Conclusion: Increased C5a activity, hypersecretion of active oxygen species (in the presence of insufficiently efficacious antioxidant system of blood), and increased atherogenic plasma index (in the presence of low levels of high-density lipoproteins) are a mechanism of endothelial dysfunction in POAG. We found an imbalance between the prooxidant and antioxidant systems, abnormal composition of blood lipids (e.g., hypercholesterolemia and hypertriglyceridemia) and elevated C5a levels in patients with POAG.
Keywords: primary open-angle glaucoma, lipid peroxidation, antioxidant system, complement components, blood lipid composition
References
1.Jiang F, Guo Y, Salvemini D, Dusting GJ. Superoxide dismutase mimetic M40403 improves endothelial function in apolipoprotein(E)-deficient mice. Br J Pharmacol. 2003;139(6):1127-34.
2.Kovacevic S, Jurin A, Didovic-Torbarina A. Dislipidmija u bolesnikas a Primarnim glaukomomotvorenogugla. Abstracts of the 7th Congress of the Croatian Ophthalmol. Society with International Participation. Ophthalmol Croatica. 2007; 16:51.
3.McGwin G Jr, McNeal S, Owsley C, Girkin C, Epstein D, Lee PP. Statins and others cholesterol-lowering medications and the presence of glaucoma. Arch Ophthalmol. 2004;122:822-6.
4.Tuychibaeva D, Rizaev J, Malinouskaya I. [Dynamics of primary and general incidence due to glaucoma among the adult population of Uzbekistan]. Oftalmologiia. Vostochnaia Ievropa. 2021;11.1:27–38. Russian.
5.Tuychibaeva DM. [Main Characteristics of the Dynamics of Disability Due to Glaucoma in Uzbekistan]. Oftalmologiia. Vostochnaia Ievropa. 2022;12.2:195-204. Russian.
6.Rizaev J, Tuychibaeva D. Study of the general state and dynamics of primary and general disability due to glaucoma of the adults in the republic of Uzbekistan and the city of Tashkent. Journal of Dentistry and Craniofacial Research. 2022;1(2):75–7.
7.Тuychibaeva DM. Longitudinal changes in the disability due to glaucoma in Uzbekistan. J Ophthalmol (Ukraine). 2022;507.4:12-17.
8.Tuychibaeva DM, Rizayev JA., Stozharova NK. Longitudinal changes in the incidence of glaucoma in Uzbekistan. J Ophthalmol (Ukraine). 2021;4:43-7.
9.Vlasova SP, Ilchenko MIu, Kazakova EB, et al. [Endothelial dysfunction and arterial hypertension]. Samara: Ofort; 2010. Russian.
10.Egorov EA, Bachaldin IL, Sorokin EL. [Characteristics of morphological and functional state of erythrocytes in patients with primary open-angle glaucoma with normalized intraocular pressure]. Vestn Oftalmol. 2001 Mar-Apr;117(2):5-8.
11.Irtegova EIu. [Role of vascular endothelial dysfunction and ocular blood flow in the development of glaucomatous optic neuropathy]. [Thesis for the degree of Cand Sc (Med)]. Moscow, 2015. Russian.
12.Félétou M, Vanhoutte PM. Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture). Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H985-1002.
13.Flammer J, Konieczka K. Retinal venous pressure: the role of endothelin. EPMA J. 2015 Oct 26; 6:21.
14.Malishevskaia TN, Kiseleva TN, Filippova IuE, et al. [Antioxidant status and blood lipid profile in patients with various courses of primary open-angle glaucoma]. Oftalmologiia. 2020;17(4):761-70. Russian.
15.Stangeby DK, Ethier CR. (September 17, 2001). Computational Analysis of Coupled Blood-Wall Arterial LDL Transport. J Biomech Eng. 2002 Feb;124(1):1–8.
16.Tezel G. Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences. Prog Retin Eye Res.2006;25:490-513
17.Bachaldin IL. [Role of blood rheology abnormalities in the progression of open-angle glaucoma with normalized intraocular pressure and developing principles for treatment of the disease]. [Thesis for the degree of Cand Sc (Med)]. Khabarovsk, 2004. Russian.
18.Lyndina ML, Shishkin AN. [Clinical features of endothelial dysfunction in obesity and the role of smoking factor]. Regionarnoie krovoobrashcheniie i mikrotsirkuliatsiia. 2018;17(2):20—7. Russian.
19.Gubin DG, Malishevskaya TN, Astakhov YS, Astakhov SY, Kuznetsov VA, Cornelissen G, Weinert D. Progressive retinal cell loss in primary open-angle glaucoma is associated with temperature circadian rhythm phase delay and compromised sleep. Chronobiology International. 2019;36(4):564-77.
20.Nofer JR, Levkau B, Wolinska I, Junker R, Fobker M, von Eckardstein A, et al. Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids. J Biol Chem. 2001 Sep 14;276(37):34480-5.
21.Mikheytseva IN. [Pathogenetic importance of endothelial dysfunction in primary glaucoma]. Dosiagnennia biologii ta medytsyny. 2009; 14(2):17-20. Russian.
22.McMonnies C. Reactive oxygen species, oxidative stress, glaucoma and hyperbaric oxygen therapy. J Optom. 2018 Jan-Mar;11(1):3-9.
23.Fujino Y, Asaoka R, Murata H. Evaluation of Glaucoma Progression in Large-Scale Clinical Data: The Japanese Archive of Multicentral Databases in Glaucoma (JAM-DIG). Invest Ophthalmol Vis Sci. 2016 Apr1;57(4):2012-20.Crossref PubMed
24.Haefliger IO, Flammer J, Beny JL, Luscher TF. Endothelium-dependent vasoactive modulation in the ophthalmic circulation. Prog Retin Eye Res. 2001;20(2):209-25.
25.Wang S, Xu L, Jonas JB, You QS, Wang YX, Yang H. Dyslipidemia and eye diseases in the adult Chinese population: The Beijing eye study. PLoS One. 2011; 6: e26871.
26.Cellini M, Strobbe E, Gizzi C, Balducci N, Toschi PG, Campos EC. Endothelin-1 plasma levels and vascular endothelial dysfunction in primary open angle glaucoma. Life Sci. 2012 Oct 15;91(13-14):699-702.
27.Davari MH, Kazemi T, Rezai A. A survey of the relationship between serum cholesterol and triglyceride to glaucoma: A case control study. J Basic Appl Sci. 2014;10:39–43.
28.Emre M, Orgul S, Haufschild T, Shaw SG, Flammer J. Increased plasma endothelin-1 levels in patients with progressive open angle glaucoma. Br J Ophthalmol. 2005 Jan;89(1):60-3.
29.Fadini GP, Pagano C, Baesso I, Kotsafti O, Doro D, de Kreutzenberg S. V, et al. Reduced endothelial progenitor cells and brachial artery flow-mediated dilation as evidence of endothelial dysfunction in ocular hypertension and primary open-angle glaucoma. Acta Ophthalmol. 2010 Feb. 88(1):135-41.
30.Kurysheva NI, Irtegova EIu, Iasamanova AN, Kiseleva TN. [Endothelial dysfunction and platelet hemostasis in primary open-angle glaucoma]. Natsional'nyi zhurnal Glaucoma. 2015;14(1):27-36. Russian.
31.Pavljasevic S, Asceric M. Primary open-angle glaucoma and serum lipids. Bosn J Basic Med Sci. 2009 Feb; 9(1):85-8.
32.Jensen JS, Feldt-Rasmussen B, Jensen KS, Clausen P, Henrik Scharling H, Nordestgaard BG. Transendothelial lipoprotein exchange and microalbuminuria. Cardiovasc Res. 2004 Jul 1;63(1):149-54.
Information about authors and disclosure of information
Corresponding author: Tuychibaeva D.M. – dyly@mail.ru.
Conflict of interest: The authors have declared that no competing interests exist.
Ethical approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Authors fulfilled the ICMJE authorship criteria.
Funding information: This research does not received specific grant from any funding agency in the public, commercial or not-for -profit sector.