https://doi.org/10.31288/oftalmolzh20134110114

Case of an Interferonogenic retinopathy of the patients with viral hepatitis C

N. N. Umanets, A. V. Lakiza

SI «The Filatov Institute of Eye Diseases and Tissue Therapy NAMS of Ukraine», Odessa, Ukraine

e-mail: avlakiza@mail.ru

Key words: viral hepatitis C, interferonogenic retinopathy, pegilyat — interferon.

In the article is presented the case of an interferonogenic retinopathy at the patient with hepatitis C. The retinopathy develops as a result of regular use pegilyat — interferon and ribavirin combination therapy of viral hepatitis C. Clinical manifes-tations of an interferonogenic retinopathy include soft exudates, intravitreal and preretinal hemorrhages, retinal neovascularization, rubeosis, macular edema, retinal vein occlusion which is accompanied by decrease of visual acuity. In this connection patients with viral hepatitis C during therapy by interferon have to be under supervision of the ophthalmologist.

References:

1.Ignatova TM. Chronic hepatitis C: clinical and morphological characteristics, course, treatment. Author's abstract. MD. M.: Pb; 2000.

2.Johnson ME, Fisher DG, Fenaughty A et al. Hepatitis C virus and depression in drug users. Am. J. Gastroenterol. 1998; 93(5): 785- 9.
Crossref

3.Yenice N, Mehtap O, Gumrah M et al. The efficacy of pe-gylated interferon alpha 2a or 2b plus ribavirin in chronic hepatitis C patients. Turk. J. Gastroenterol. 2006;17: 94-8.

4.Hayasaka S, Nagaki Y, Matsumoto M et al. Interferon as-sociated retinopathy. Br. J. Ophthalmol. 1998; 82: 323- 5.
Crossref

5.Goncalves LL, Farias AQ, Goncalves PL et al. Branch retinal vein thrombosis and visual loss probably associated with pegylated interferon therapy of chronic hepatitis C. World. J. Gastroenterol. 2006;12: 4602- 3.
Crossref

6.Malik NN, Sheth HG, Ackerman N et al. A prospective study of change in visual function in patients treated with pegylated interferon alpha for hepatitis C in the UK. Br. J. Ophthalmol. 2008; 92: 256- 8.
Crossref

7.Jain K, Lam WC, Waheeb S et al. Retinopathy in chronic hepatitis C patients during interferon treatment with ribavirin. Br. J. Ophthalmol. 2001; 85: 1171-3.
Crossref

8.Hayasaka S, Fujii M, Yamamoto Y et al. Retinopathy and subconjunctival haemorrhage in patients with chronic viral hepatitis receiving interferon alfa. Br. J. Ophthalmol. 1995; 79: 150-2.
Crossref

9.Okuse C, Yotsuyanagi H, Nagase Y et al. Risk factors for retinopathy associated with interferon alpha-2b and riba-virin combination therapy in patients with chronic hepatitis C. World. J. Gastroenterol. 2006; 12: 3756-9.
Crossref

10.Nagaoka T, Sato E, Takahashi A et al. Retinal circulatory changes associated with interferon-induced retinopathy in patients with hepatitis C. Invest. Ophthalmol. Vis Sei. 2007; 48: 368- 75.
Crossref

11.Manesis EK, Petrou C, Brouzas D et al. Optie traet neu-ropathy eomplieating low-dose interferon treatment. Hepatol. 1994; 21: 474- 7.
Crossref

12.Ayaki M. Development of neovaseular glaueoma in the eourse of interferon alfa therapy for hepatitis type C. Br. J. Ophthalmol. 1994; 78: 238.
Crossref

13.Tu KL, Bowyer J, Schofield K et al. Severe interferon assoeiated retinopathy. Br. J. Ophthalmol. 2003; 87: 247-8. 
Crossref