http://doi.org/10.31288/oftalmolzh201026772

THE FUNCTIONAL STATE OF RETINA MITOCHONDRIA IN MODELING OF THE GLAUCOMATOUS PROCESS

Serduyk V.N.

Dnepropetrovsk, Ukraine

There was investigated the functional state of the optical nerve and retina mitochondria in modeling of the glaucomatous process. It is established that in development of the glaucomatous process in the experiment the system of oxidation of the biosubstances is disturbed in the retina. The indices of the activity of oxidoreductases of mitochondria are progressively reduced in proportion to development of the pathologic process. The state of the membran-otransporting processes in the nerve cell mitochondria in modeling of glaucoma is substantially reduced from the very beginning of glaucoma development.

 

References

1.Исаев Н. К., Андреева Н. А. Роль митохондрий в механизмах токсического действия глутамата. — Биохи¬мия. — 2005. — Т. 70. — Вып. — 6. — С. 741-750.

2.Лакин Г. Ф. Биометрия. —  М.: Высшая школа. — 1990. — 352 с.

3.Луценко Н. С. Гормонально-метаболические нарушения при первичной открытоугольной глаукоме и патогенетическое обоснование их коррекции в комплексном лечении: автореф. дис. канд. мед.наук : 14.01.18. — Запорожье. — 2007. — 18 с.

4.Наследов A. SPSS компьютерный анализ данных в психологии и социальных науках. // Спб.: Питер, 2005. — 416 с

5.Новые методы биохимического анализа. // Изд. Ленинградского универ. — 1991. — 395 с.

6.Agar A., Li S. Retinal ganglion cell line apoptosis induced by hydrostatic pressure / Brain Res. — 2006. — V. 1086. — P. 191-200.
Crossref

7.Benozzi J., Nahum L. P., Campanelli J. L. Effect of hyaluronic acid on intraocular pressure in rats / Invest. Ophthalmol. Vis. Sci. — 2002. — V.43. — P. 2196-2200.

8.Bergamini С. M., Gambetti S., Dondi A. Oxygen, reactive oxygen species and tissue damage. // Cur.Pharm. Design. — 2004. — Vol. 10 (14). — P. 1611 - 1626.
Crossref

9.Bergmeyer H. U. Methoden der enzymatischen analyse. — Akademi-Verlag, Berlin. — 1970. — P. 1667-1670.

10.Boland M. V., Quigley H. A. Risk factors and open-angle glaucoma: classifications and application / J Glaucoma. — 2007. — V. 16. — № 4. — P. 406-418.
Crossref

11.Carter-Dawson L., Crawford M. L., Harwerth R. S. Vitreal glutamate concentration in monkeys with experimental glaucoma. — 2002. — V. 43. — P. 2633-2637.

12.Cherghel D., Griffiths H. R., Hilton E. J. Systemic reduction in glutathione levels occurs in patients with primary open angle glaucoma / Invest. Ophthalmol. Vis. Sci. — 2005. — V. 46. — P. 877-883.
Crossref

13.Chidlow G., Wood J. P. M., Casson R. J. Pharmacological neuroprotection for glaucoma / Drugs. — 2007. — V. 67. — № 5. — P. 725-759.
Crossref

14.Dun Y., Mysona B. Expression of the cysteine-glutamate exchanger in retinal ganglion cells and regulation by nitric oxide and oxidative stress / Cell Tissue Res. — 2006. — P. 1-14.

15.Govindarajan B., B. Govindarrajan, J. Laird, R. Sherman. Neuroprotection in glaucoma using calpain-1 inhibitors: regional differences in calpain-1 activity in the trabecular meshwork, optic nerve and implications for therapeutics / Neurol Disord Drug Target. — 2008. — V. 7. — № w3. — P. 295-304.
Crossref

16.Guo L., Salt T. E., Maass A. Assessment of neuroprotective effects of glutamate modulation on glaucoma related retinal ganglion cell apoptosis in vivo / Invest. Ophthalmol. Vis. Sci. — 2006. — V. 47. — P. 626-633.

17.Harada T., Harada C., Nakamura K. The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma / J. Clin. Invest. — 2007. . — V. 117. — №7. — P. 1763-1770.

18.Honkanen R. A., Baruah S., Zimmerman M. B. Vitreous amino acid concentrations in patients with glaucoma undergoing vitrectomy / Arch. Ophthalmol. — 2003. — V. 121. — P. 183-188.
Crossref

19.Johnson T. V., Bull N. D., Hunt D. P. Local mesenchymal stem cell transplantation confers neuroprotection in experimental glaucoma / Invest Ophthalmol. Vis. Sci. — 2009. — V. 20. — P. 356-359.

20.Kim C. I., Lee S. H. Nuclear translocation and overex-pression of GAPDH by the hyper-pressure in retinal ganglion cells / Biochem. Biophys. Res. Commun. — 2006. — V. 341. — P. 1237-1243.
Crossref

21.Kumar D. M., Agarwal N. Oxidative stress in glaucoma: a burden of evidence / J Glaucoma. — 2007. — V. 16. —P. 334-343.
Crossref

22.Lambiase A., Aloe L., Centofanti M., et al. Experimental and clinical evidence of neuroprotection by nerve grow3th factor eye drops: implications for glaucoma / Proc. Natl. Acad. Sci. — 2009. — V. 106. — № 32. — P. 13469-13474.
Crossref

23.Lieven C. J., Vrabec J. P., Levin L. A. The effect of oxidative stress on mitochondrial transmembrane potential in retinal ganglion cells / Antioxid. Redox. Signal. — 2003. — V. 5. — № 5. — P. 641-646.

24.Lipton S. A. Pathologically activated therapeutics for neuroprotection / Nature Reviews Neurosci. — 2007. —V. 8. — P. 803-808.

25.Madl J. E. Mcllnay T. R. Depletion of taurine and glutamate from damaged photoreceptors in the retina of dogs with primary glaucoma / Am J Vet. Res. — 2005. — V. 66. — P. 791-799.

26.Martin K. R., Levkovitch-Verbin H., Valenta D. Retinal glutamate transporter changes in experimental glaucoma and after optic nerve transaction in therat / Invest. Oph- thalmol. Vis. Sci. — 2002. — V. 43. — P. 2236-2243.

27.Mates J., Segura J., Alonso F. Pathways from glutamine to apoptosis / Front. In Bioscience. — 2006. — V. 11. —P. 3164-3180.

28.Moraczewski A. L., Lee R. K., Palmberg P. F. et al. Out-comes of treatment of neovascular glaucoma with intravitreal bevacizumab / Br J Ophthalmol. — 2009. — V. 93. — P. 589-593.

29.Moreno M. C, Sande P., Marcos H. A. Effect of glaucoma on the retinal glutamate/glutamine cycle activity / FASEB J. — 2005. — V. 19. — № 9. — P. 1161-2.

30.Moreno M. C, Marcos H. A. A new experimental model of glaucoma in rats through intracameral injection of hyaluronic acid / Exp. Eye Res. — 2005.

31.Moreno M. C, Campanelli J. L., Sande P. Retinal oxidative stress induced by high intraocular pressure / Free Radic. Biol. Med. — 2004. — V. 37. — P. 803-812.

32.Moreno M. C, Croxatto J. P., Campanelli J. L. Retinal damage-after the chronic injection of hyaluronic acid in the rat anterior chamber / Invest. Ophthalmol. Vis. Sci. — 2002. — V. 43. — P. 2158.

33.Neufeld A. H. Pharmacologic neuroprotection with an inhibitor of nitric oxide synthase for the treatment of glaucoma / Brain res. Bull. — 2004. — V. 62. — P. 455-459.

34.Nucci C, Tartaglione R., Rombola L. Neurochemical evidence to impkicate elevated glutamate mechanisms of high intraocular pressure-induced retinal ganglion cell death in rat / Neurotoxicology. — 2005. — V. 26. — P. 935-941.

35.Osborne N. N., Li P., Mortiboys H. L, Jackson S. Light affects mitochondria to cause apoptosis to cultured cells: possible relevance to ganglion cell death in certain optic neuropaties / J Neurochem. — 2008. — V. 105. — № 5. —P. 2013-2028.

36.Pache M., Flammer J. A sick eye in a sick body? Systemic findings in patients with primary open-angle glaucoma / Surv. Ophthalmol. — 2006. — V. 51. — № w3. — P. 179-212.

37.Roh Y., Moon C, Kim S. Glutathione depletion induces differential apoptosis in cells of mouse retina, in vivo. // Neuroscience Let. — 2007. — Vol. 417(3). — P. 266-270.

38.Saenz D. A., Goldin A. P. Minces L. Effect of the retinal glutamate/glutamine cycle in the golden hamster retina / The FASEB J. — 2004.

39.Schober M. S., G. C. Childlow et al. Bioenergetic-based neuroprotection and glaucoma / Clin. & Exp. Ophthalmol. — 2008. — V. 36. — № 4. — P. 377-385.

40.Shen F., Chen В., Danias J. Glutamate-induced glutamine synthetase expression in retinal Muller cells after short-term ocular hypertension in the rat / Invest. Ohthalmol. Vis. Sci. — 2004. — V. 45. — P. 3107-3112.

41.Tezel G., Yang X, Cai J. Proteomic identification of oxi-datively modified retinal proteins in a chronic pressure-induced ret model of glaucoma / Invest. Ophthalmol. Vis. Sci. — 2005. — V. 46. — P. 3177-3187.

42.Wamsley S., Gabelt в. Т., Dahl D. B. Vitreous glutamate concentration and axon loss in monkeys with experimental glaucoma / Arch. Ophthalmol. — 2005. — V. 123. — P. 64-70.

43.Weber A. J., С D. Harman, S. Viswanathan. Effects of optic nerve injury, glaucoma, and neuroprotection on the survival, structure, and function of ganglion cells in the mamma¬lian retina / J Physiol. — 2008. — V. 18. — P. 4393-4400.

44.Xiong Y. Prevention of mitochondrial dysfunction in post-traumatic mouse brain by superoxide dismutase / Y. Xiong, F S. Shie, J. Zhang // J Neurosci. —   2005. — V. 95. — P. 732-744.