Oftalmol Zh. 2013;6:62-67.

https://doi.org/10.31288/oftalmolzh201366267

Improvement of ablation enucleation of the eyeball in retinoblastoma

Pasechnikova NV, Bobrowa NF, Naumenko VA, Sorochinskaya TA, Levitsky IM

SI «The Filatov Institute of Eye Diseases and Tissue Therapy NAMS of Ukraine, Odessa

Introduction. Retinoblastoma (RB) are more often diagnosed (77—91 %) in the advanced T3-T4 stages. That's why enucleation (tumor removal within the eye- ball) is the only way to save child's life with advanced RB.

Purpose. To develop and implement enucleation method of advanced RB, allowing to improve ablastic of surgery.

Material and methods. The authors have developed enucleation method advanced RB using high-frequency electric welding for optic nerve cutting. 21 primary enucleation in 21 patients at age 3 mo/o to 6 y/o with RB T3—4b stages were performed. Long-term results (6—49months) were evaluated in 10children (10eyes). 

Results and discussion. No bleeding or tissue edemas were noted during surgery. This allowed to avoid tamponade of orbit, reduce duration of surgery, visualize the orbital part of the optic nerve and additionally resect its fragment by electric welding, which increased the probability of tumor removing within healthy tissues. In follow-up continued tumor growth, orbit and distant metastases were not found in any cases. 

Conclusions. Developed method of enucleation for eyes with advanced RB using high-frequency electric welding allowed to achieve improving of surgery ablastic. This prevents the development of orbital tumor relapse, continued growth in the brain and hematogenous metastasis.

Key words: retinoblastoma, enucleation, ablastic of surgery

References

1.Arkhangelsk? VN. Guide on eye diseases. Valume 4. Book 1. 1959.

2.Bobrova NF, Sorochinskaya TA. Clinical and diagnostic features of retinoblastoma in Ukraine. Proceedings of scientific practical conference «Current problems of ophthal-mology». Ufa. 2009. 778- 83.

3.Bobrova NF, Sorochinskaya TA. New trends in treatment of retinoblastoma in children. Proceedings of international scientific conference dedicated to Puchkovskaya N. A. Odessa. 2008. 259- 260.

4.Brovkina AF. Modern concept of retinoblastoma treatment. Vestn Oftalmol. 2005; 2: 48-51. Russian.

5.Dybov S. Retinoblastoma. Sofia; 1975. 126 p.

6.Kallahkan AN. Eye diseases surgery. Moscow; 1963. 488 p.

7.Saakayan SV. Retinoblastoma (Clinics, diagnostics, treat-ment). M.: Meditsina; 2005. 200 p.

8.Saakayan SV. Modern approaches to retinoblastoma treat-ment. Rossiiskii oftalmologicheskii zhurnal. 2008; 1: 338. Russian.

9.Hawkins MM, Kingston JE, Kinnier Vt?lson LM. Late deaths after treatment for childhood cancer. Arch Dis Child. 1990; 65:1356-63.
Crossref

10.Honavar SG, Singh AD, Shields CL et al. Postenucleation adjuvant therapy in high-risk retinoblastoma. Arch Oph-thalmol. 2002; 120:923- 31.
Crossref

11.Liotta LA. An attractive force in metastasis. Nature. 2001; 410:24-5.
Crossref

12.Magramm I, Abramson DH, Ellsworth RM. Optic nerve involvement in retinoblastoma. Ophthalmology. 1989; 96:217-22.
Crossref

13.Marback EF, Arias VE, Paranhos A Jr, et al. Tumour angiogenesis as a prognostic factor for disease dissemination in retinoblastoma. Br J Ophthalmol. 2003; 87:1224- 8.
Crossref

14.Messmer EP, Heinrich T, Hupping W, et al. Risk factors for metastases in patients with retinoblastoma. Ophthalmology. 1991; 98:136-41.
Crossref

15.Shields CL, Mashayekhi A, MD; Cater J et al. Macular Retinoblastoma Managed With Chemoreduction . Analysis of Tumor Control With or Without Adjuvant Thermo-therapy in 68 Tumors Arch Ophthalmol. 2005;123:765- 773.
Crossref

16.Wang AG, Hsu WM, Hsia WW, et al. Clinicopathologic factors related to metastasis in retinoblastoma. J Pediatr Ophthalmol Strabismus. 2001; 38:166- 71.