https://doi.org/10.31288/oftalmolzh201368690

State of the enzymatic antioxidant system in the modeling of cataracts and age-related effects of flavonoids

Leus NF, Girzheva AV, Zhuravok YA

SI «The Filatov Institute of Eye Diseases and Tissue Therapy NAMS of Ukraine», Odessa

Introduction. The urgency of work is determined by necessity to find out the effect of flavonoids in treatment of age-related cataract.

Purpose. To study a condition of the enzymic antioxidant system in modelling age-related cataract and influence of flavonoids. 

Material and methods. The investigations have been made in 32 rabbits divided into three groups: a control group — 8 rabbits, a group «light» — 12 rabbits, and a group «light+flavonoids» — 12 rabbits. Determination of the contents of superoxide dismutase, catalase and glutathione peroxidase was made in the lens homog-enates and chamber humor.

Results. Quercetin substantially prevents sharp inhibition of the neutralization processes of lipid hydroperoxides in the lens under the influence of the caractogenic factor by means of stabilization of the glutathione peroxidase enzyme, which activity was by 58.8 % higher than in the group with light influence without application of flavonoid.

Conclusions. As a result of the experimental investigations it was established that flavonoid — quercetin substantially exerts a protective influence on enzymes of the antioxidant system in the lens and chamber humor of animals with age-related cataract.

Key words: age-related cataract, antioxidant system, flavonoids, experiment.

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