https://doi.org/10.31288/oftalmolzh201362225

Peculiarities of chromatic optic canals activity at different stages of primary glaucoma

Stotska LM1, Stotska LS2

1GU «Ivano-Frankivsk Medical University» (Department of Neurosurgery and Ophthalmology)

2 Ivano-Frankivsk city hospital № 3, Ivano-Frankivsk, Ukraine

Introduction. Morphologic changes in the ganglion cells of the retina and optic nerve on an average by 5—7 years forestall the clinical manifestations of the disease. Standard methods of examination are not specific to different types of the ganglion cells of the retina therefore in using achromatic methods of diagnosis, defects of the visual functions can be revealed only in absolute loss of the whole pool of gangliocytes.

Purpose. To study the peculiarities of the chromatic optic canals activity in their selected activation by different light stimulus at different stages of the glaucoma process. 

Materials and methods. Clinical and functional studies were made in patients with primary open-angle glaucoma (POAG). The main group consisted of 119patients (138 eyes): preglaucoma — 39 (78 eyes), initial — 70 (80 eyes), advanced — 40 (80 eyes). The age ranged 40— 60, the mean age was (51.8+3.2). The control group comprised 60patients, the mean age was (52.4+3.1) consisting of patients without primary glaucoma. There were used additional electrophysiological methods of investigation: critical rate of flicker fusion (CRFF) and critical rate of flicker appearance (CRFA) to different light stimulus (white, blue, green, yellow, red). Results. While analyzing the indices of CRFF and CRFA to different light stimulus (white, blue, green, yellow, red) we obtained the most marked reliable changes to the blue stimulus already at the early stages of POAG: 25.94 % and 29.2 % accordingly, lower than in the control group. There were also revealed more marked reliable changes of CRFF in comparison with CRFA to all proposed light stimulus at all stages of the glaucoma process.

Conclusion. The results of the study are evidence of prevailing damage of the dark terminals of the blue cones bipolar cells of the retina already at the early stage of development of the glaucoma process. The data obtained indicate the expediency of using blue light stimulus to reveal early manifestations of the primary glaucoma process

Key words: primary open-angle glaucoma, the retina, chromatic visual canals

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