https://doi.org/10.31288/oftalmolzh201611923

Study of visual evoked potentials in clinical practice in the patients with primary open-angle glaucoma

L.M. Stotska, Cand. Sc (Med)

I.B. Chokova, Cand. Sc (Med)

K.S. Romodanova

V.B. Reshetniak

State Institution “The Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine”

Odessa (Ukraine)

Introduction. It is known that in clinical practice there are no specific neurophysiological tests for diagnosis of glaucoma; however, quite often neurophysiological examination reveals changes which are asymptomatic for a long time before the clinical manifestations, which is especially important for the early diagnosis of glaucoma.

Purpose of the study is to make a dynamic analysis of visual evoked potentials in patients with primary open-angle glaucoma at different stages of the disease.

Material and Methods: a comprehensive clinical and neurophysiological study of 186 patients (358 eyes) with the diagnosis of primary open-angle glaucoma and in patients whose diagnosis was a subject to confirmation.

Results: Based on the analysis of the results of neurophysiological studies, visual evoked potentials in response to pattern and flash, we saw a statistically significant difference between the initial and advanced stages in terms of the latent period P100 (Z = 2.33; p-value = 0.028), the amplitude of peaks P100-N135 (Z = 3.50 p-value = 0.00046), the amplitude of peaks P100-N75 (Z = 2.04; p-value = 0.04); between the advanced and far-advanced stages in terms of the latent period P100 (Z = 3.08; p-value = 0.033). According to the other studied estimates of indicators of visual evoked potentials in response to pattern and flash we did not find any significant differences.

Conclusion. Usage of neurophysiological study methods visual evoked potentials in response to pattern is necessary for confirmation of the diagnosis and stage of development of glaucoma during the early diagnosis and the choice of further tactics of treatment.

Key words: primary open-angle glaucoma, visual evoked potentials, visual cortex

References

1.        Alekseev VI, Nikitin DI, Gazizova IR.  [Changes in the central parts of visual analyzer in case of primary open-angle glaucoma]. Collection of abstracts from research and practice conference “Filatov Readings – 2012”. Odessa. 2012: 95. Russian.

2.        Zavgorodnyaya NV, Pasechnikova NV. [Primary glaucoma. Fresh approach to the old problem]. Zaporozhzhye. 2010:192. Russian.

3.        Kisseleva OA, Makuha SA, Yakubova AV, Vasilenkova LV. [Examination of eye haemodynamics in patients with primary open angle glaucoma after fistulizing surgery]. Rossiysky oftalmologicheskiy zhurnal. 2014;7(2):94-96. Russian.

4.        Lessella S, Van Dalena JTU.  [Neuroophthalmology]. Moscow: Meditsina. 1983:99-101. Russian.

5.        Moiseenko RA, Golubchikov MV, Slabkiy GO, Rykov SA. et al. [Ophthalmological care in Ukraine in 2006-2011]. Kiev;2:183. Russian.

6.        Rykov SA, Vitovskaya OP, Shargorodskaya IV et al. [Unified clinical protocol of medical care. Primary open angle glaucoma. Primary and secondary care]. Order of the Ministry of Health of Ukraine No. 816, dated 24.11.2011. Kiev. 2011:37. Russian.

7.        Shamshinova АМ , Andreeva TM. [Clinical physiology of sense of vision]. Moscow. 2006:956. Russian.

8.        Alekseev V, Gаzizova I. Meaning of neurodegeneration in the pathogenesis of glaucoma, 11 th EGS Congress. Nice. 2014:60.

9.        Berisha F et al. Effect of trabecullctomy on ocular blood flow. Br. J. Ophthalmol. 2005;89 (2):185-8.
        Crossref   Pubmed

10.     Hasegawa S, Abe H. Mapping of glaucomatous visual field defects by multifocal VEPs. Inv. Ophthalmol. Vis.Sci. 2001;42:3341–3348.

11.     Hood DC, Odel JG, Winn BJ. The multifocal visual evoked potential. J. Neuroophthalmol. 2003;23(4):279-289.
        Crossref   Pubmed

12.     Klistorner A, Graham SL. Objective perimetry in glaucoma. Ophthalmol. 2000;107:2283–2299.
        Crossref   Pubmed

13.     Klistorner A, Graham SL, Grigg JR. et al. Multifocal topographic visual evoked potential: improving objective detection of local visual field defects. Inv. Ophthalmol. Vis. Sci. 1998;39(6):937 – 950

14.     Nesher R, Mimouni M, Epshtein E, Gorck L, Trick C. Reported status OCT retinal nerve fiber Layer thicrness measurements. In: Natsionaln. zhurn. glaukomy. 2014;2(13):11-15.

15.     Quigley UA. Glaucoma. Lancet. 2011:16;377(9774):1367–7.
        Crossref   Pubmed

16.     Wu De Zheng, Liu Yan Atlas of testind and clinical application for Roland Electrophysiolodikal Instrument. Beigind science and technology Press. China, 2006:5-19.