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http://doi.org/10.31288/oftalmolzh202234549

Received: 11.11.2020; Accepted: 02.06.2022: Published on-line 15.06.2022

Assessing the impact of anti-inflammatory interleukin IL-10 and flosteron, a long-acting corticosteroid, on the course of corneal burn process 

S. A. Iakymenko, O. V. Dzhygaliuk, M. V. Gavryliuk

SI "The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine"; Odesa (Ukraine) 

TO CITE THIS ARTICLE:Iakymenko SA, Dzhygaliuk OV, Gavryliuk MV. Assessing the impact of anti-inflammatory interleukin IL-10 and flosteron, a long-acting corticosteroid, on the course of corneal burn process. J.ophthalmol.(Ukraine).2022;3:45-9.     http://doi.org/10.31288/oftalmolzh202234549

Background: Ocular burns are the most severe injury to the eye, and their treatment is still a challenge.

Purpose: To assess the temporal changes in and grades of major characteristics of the corneal burn process after anterior chamber injection of anti-inflammatory interleukin (IL)-10 versus subconjunctival injection of flosteron, a long-acting corticosteroid.

Material and Methods: Eighteen Chinchilla rabbits were divided into 3 groups of six each, and the right eye of all rabbits received an experimental burn. Thereafter, the right eye of rabbits of group 1 received anterior chamber IL-10 injection, the right eye of rabbits of group 2, subconjunctival flosteron injection,  and the right eye of rabbits of group 3 (the control group), a drop of Floxal in the conjunctival sac at days 3, 7, 21 and 30.

Results: The main characteristics of corneal inflammatory process (corneal opacity (edema), ocular inflammation, corneal erosion, vascularization, and leucoma) changed with time after burn, and were closely associated with each other, but the scores of these characteristics were lower in the rabbits of groups 1 and 2 compared to controls. In addition, the scores were higher in the rabbits that received IL-10 injections compared to those that received subconjunctival flosteron injections.

Conclusion: Subconjunctical corticosteroid injections can be reasonably used for inflammation in ocular burns, and are more advantageous than interleukin injections in the anterior chamber in terms of easy use, safety and availability.

Keywords: ocular burns, IL-10, inflammatory process, corticosteroids, flosteron

 

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Disclosures

Corresponding author. Dzhygaliuk O.V., email: dovgalenko1@ukr.net

Author contribution. Iakymenko S.A.: design, participation in the experiment, data analysis, editing the article; Gavryliuk M.V.: conducting an experiment, initial data analysis, writing an article; Dzhiygalyiuk O.V.: participation in the experiment, data analysis, writing the article. All authors analyzed the results and approved the final version of the manuscript. 

Sources of support. None

Conflict of interest. The authors do not have any real or potential conflicts of interest (financial, personal, professional and other interests) that could affect the content and conclusions of the work.