https://doi.org/10.31288/oftalmolzh201662931

Prevalence of ocular diseases in patients with pulmonary tuberculosis and HIV infection
A.V. Zborovskaia, Dr Sc (Med)
N.V. Konovalova, Dr Sc (Med)
T.S. Pyl’kevich, Cand Sc (Med)
A.E. Dorokhova, Cand Sc (Med)
L.A. Iurchenko, Research Fellow
Filatov Institute of Eye Diseases and Tissue Therapy, NAMS of Ukraine
Odessa, Ukraine
E-mail: filatov.uveitis@gmail.com
Background: Given the high prevalence and rate of disability from ocular pathologies, it is clinically and socially important to determine their prevalence in patients with tuberculosis and HIV infection.
Purpose: To determine the prevalence of ocular diseases in patients with tuberculosis and HIV infection.
Materials and Methods: Medical records related to regular medical check-up of 212 patients with tuberculosis (including those co-infected with HIV) at the Odessa Region Tuberculosis Dispensary in the year 2015 were retrospectively analyzed.
Results: Ocular involvement was found in 86 (40.5%) patients (52 (60.4%) men and 34 (39.5%) women; mean age, 32.43 ± 7.45 years). Out of them, 52 (60.4%) patients (70 eyes) had both pulmonary and lymph node tuberculosis, whereas 34 (39.6%) patients had both tuberculosis and HIV. Focal chorioretinitis, disseminated chorioretinitis, keratitis, optic neuritis, scleritis and iridocyclitis were found in 31.3%, 22.09%, 17.44%, 8.13%, 8.13%, and 12.79%, respectively, of patients.
Conclusion: Given the high prevalence of ocular pathology in patients with tuberculosis and HIV, ophthalmologists should give special attention to them. Posterior segment disorders (focal or disseminated chorioretinitis or optic neuritis) accounted for a major portion (61.52%) of the burden of ocular pathology in these patients. The frequency of glaucoma and hemorrhagic complications (retinal periphlebitis or vasculitis) in HIV-positive tuberculosis patients were 7.5 times and 6 times, respectively, higher than those in non-HIV tuberculosis patients.
Key words: tuberculosis, HIV infection, ocular diseases       
References
1.    Batyrov FA, Khomenko VA, Shmakova LN. [Epidemiology of extrapulmonary tuberculosis]. Problemy tuberkulioza. 2003; 8:49–50 Russian
2.    Centers for Disease Control. Fact Sheet: Tuberculosis in the United States. – Retrieved on 6 October 2006.
3.    [National Women’s Forum on HIV and AIDS: women’s faces of the HIV epidemics in Ukraine]. 16.09.2016. Kyiv. 2016 Russian
4.    Khidzhak TV, Pan’kov NS. [Ocular pathology in HIV-positive patients]. In: [Important infections in the 21st century. Proceedings of the Conference on the 120th anniversary of the Botkin Infectious Hospital]. St Petersburg 2002 p.156-7 Russian
5.    Marchenko NR, Shakhgildian VI. [Viral infections of the eye in HIV-positive patients]. Epidemiologiia I infektsionnyie bolezni. 1998;5:36–38 Russian
6.    Vartanian FE, Shakhovskyi KP. [Tuberculosis: issues and research in countries of the world]. Problemy tuberkulioza. 2002; 2:48–50 Russian
7.    World Health Organization. What is DOTS? A guide to understanding the WHO-recommended TB-control strategy known as DOTS. Geneva: WHO press.  1999
8.    [World Tuberculosis Day]. Voprosy ekonomiki i upravleniia dlia rukovoditelei zdravookhraneniia. 2009; 4:62–78 Russian
9.    Konovalova NV, Degtiarenko TV. [Epidemiology of ocular tuberculosis in the global burden of tuberculosis]. Oftalmol Zh. 2007;1:6–11 Russian
10.    Khokkanen VM. [Ocular tuberculosis]. In: Brazhenko AN, editor. [Extra-pulmonary Tuberculosis: A Manual for Physicians]. St Petersburg: Spetsial’naya Literatura; 2013 pp.375-92 Russian