http://doi.org/10.31288/oftalmolzh202048388

Received: 05 June 2020; Published on-line: 27 August 2020

Mathematical modelling in ranking timolol single active ingredient drugs by the efficacy criterion

V.M. Sakovych1,  O.V. Makarenko1, O.V. Kryvoviaz 2, Yu.O. Tomashevska2,  V.M. Koval2

1Dnipropetrovsk Medical Academy, Ministry of Health of Ukraine; Dnipropetrovsk (Ukraine)

2 National Pirogov Memorial Medical University, Vinnytsya (Ukraine)

E-mail: tomasevskau@gmail.com

TO CITE THIS ARTICLE: Sakovych VM, Makarenko OV, Kryvoviaz OV, Tomashevska YuO, Koval VM. Mathematical modelling in ranking timolol single active ingredient drugs by the efficacy criterion. J.ophthalmol.(Ukraine).2020;4:83-88. http://doi.org/10.31288/oftalmolzh202048388

Background: Glaucoma is a disease that is associated with elevated intraocular pressure. Most commonly, single active agent beta-adrenoceptor blockers (particularly, timolol-only preparations) are used as a first-line therapy for primary open-angle glaucoma (POAG).

Purpose: To compare the efficacy of various timolol-only preparations available in the Ukrainian pharmaceutical market as a monotherapy for POAG on the basis of expert assessment.

Methods: Forty-four ophthalmologists from various Ukrainian regions participated in the questionnaire survey. The participants varied in length of service, academic degree and experience in managing the disease. Survey data were processed using the method of the prior ranking of factors.

Results: Mathematic modeling was used to construct the bar chart of ranks from the processed results of the survey. The overall impact of any factor on the examined variable was assessed through the sum of ranks.

Conclusion: The method of the prior ranking of factors was used to establish that, in the opinion of the surveyed ophthalmologists, CUSIMOLOL, ARUTIMOL and OFTAN TIMOLOL are the three most efficient timolol-only preparations for the treatment of POAG.

Keywords: a priori ranking, glaucoma, Timolol drugs

 

References 

1.Kryvov’iaz OV. [Glaucoma patients’ quality of life: social and pharmacoeconomic aspects]. Dnipro: Litograf; 2017. Ukrainian.

2.European Glaucoma Society. Terminology and guidelines for glaucoma. 4th ed. Savona: PubliComm; 2014. 

3.Groshovyi TA, Martseniuk VP, Kucherenko LІ, et al. [Mathematic planning of experiments in pharmaceutical research]. Ternopіl: Ukrmedkniga; 2008. Ukrainian.

4.Babintseva LIu. [Expert survey to assess the efficacy of medications]. Medychna informatika ta inzheneriia. 2014;1:21-3. Ukrainian.

5.The State Register of Medicinal Products of Ukraine. Available from: http://www.drlz.com.ua. Ukrainian.

The authors certify that they have no conflicts of interest in the subject matter or materials discussed in this manuscript.