Oftalmol Zh.2009;1-2:92-97.
http://doi.org/10.31288/oftalmolzh2009129297
DYSFUNCTION OF MITOCHONDRIAL STRUCTURES OF THE RETINA IN EXPERIMENTAL DIABETES AND POSSILITIES OF THEIR CORRECTION
Gladush T. I., Bajdan E. I.
Odessa, Ukraine
The functional condition of mitochondria of the retinal membrane was investigated in modeling of experimen¬tal diabetes in white rats.
There was revealed reduced activity of enzymic systems of mitochondrial matrix and internal mitochondrial membrane that reflected the essence of impaired oxidation-reduction and biopower processes in the retina in ex¬perimental diabetes.
The data obtained show the most important chain of the mechanism of development of diabetic retinopathy in modeling of diabetes.
The work also presents data about a possibility of correction of the functional status of mitochondria by means of thiol preparations (acetylcistein or taurine) and bioflavonoids (rutin).
References
1.Александровский А. Я. Молекулярные механизмы развития диабетических осложнений // Биохимия. — 1998. — Т. 63, № 11. — С. 1470-1479.
2.Леус Н. Ф. Метаболические механизмы развития и перспективы медикаментозного лечения диабетической ретинопатии // Офтальмол. журн. — 2003. — № 5. — С. 75-80.
3.Леус Н. Ф., Олейник Т. В., Коломийчук С. Г. Влияние препаратов витамина В1 (кокарбоксилазы и бенфотиамина) на биофизические и метаболические процессы в сетчатке и плазме крови белых крыс со стрептозотоциновым диабетом // Офтальмол. журн. — 2007. —№ 2. — С. 70-75.
4.Наследов А. SPSS компьютерный анализ данных в психологии и социальных науках. — СПб.: Питер, 2005. — 416 с.
5.Новые методы биохимического анализа. — Изд. Ленинградского универ., 1991. — 395 с.
6.Полторак В. В., Блох К. О., Малашенко А. М. Экспериментальное моделирование сахарного диабета для изучения специфического эффекта новых антидиабе-тических веществ / Методические рекомендации. — Харьков, 1991, — 19 с.
7.Aliciguzel Y., Ozen I., Aslan M. Activities of xanthine oxidoreductase and antioxidatn enzymes in different tissues of diabetic rats // J. Lab. & Clin. Med. — 2003. — Vol. 142 (3). — P. 172-177.
8.Barber A. J. A new view of diabetic retinopathy: a neurodegenerative disease of the eye // Prog. In Neoro-Psychopharm. & Biol. Psych. — 2003. — Vol. 27. — P. 283-290.
9.Bearse M., Adams A., Han Y. A multifocal electroretinogram model predicting the development of diabetic retinopathy // Ret. & Eye Res. — 2006. — Vol. 25. — P. 425-448.
10.Bergamini C. M., Gambetti S., Dondi A. Oxygen, reactive oxygen species and tissue damage // Cur. Pharm. Design. — 2004. — Vol. 10 (14). — P. 1611-1626.
11.Bergmeyer H. U. Methoden der enzymatischen Analyse. — Herausgegeben von H. U. Bergmeyer. — Berlin. —1986. — S. 2254-2265.
12.Bloomgarden Z. T. Diabetic retinopathy and diabetic neuropathy // J. Diabetes Care. — 2007. — Vol. 30 (3). — P. 760-765.
13.Brownlee M. The pathobiology of diabetic complications (a unifying mechanism) // J. Diabetes. — 2005. — Vol. 54. — P. 1615-1625.
14.Du Y., Miller C. M., Kern T. S. Hyperglecemia increases mitochondrial superoxide in retina and retinal cells // Free Rad. Biol. & Med. — 2003. — Vol. 35 (11). — P. 1491-1499.
15.Kanwar M., Chan P.-S., Kern T. S. Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase // Invest. Ophthalmol. Vis. Sci. — 2006. — Vol. 47. — P. 1594-1599.
16.Kowluru R. A. Diabetic retinopathy: mitochondrial disfunction and retinal capillare cell death // Antioxid. & Re-dox. Signal. — 2005. — Vol. 7 (11-12). — P. 1581-1587.
17.Kowluru R. A., Abbas S. N. Diabetes-induced mitochondrial dysfunction in the retina // Invest. Ophthalmol. Vis. Sci. — 2003. — Vol. 44 (12). — P. 5327-5334.
18.Kowluru R. A., Atasi L., Ho Y. S. Role of mitochondrial superoxide dismutase in the development of diabetic retinopathy // Invest. Ophthalmol. Vis. Sci. — 2006. — Vol. 47 (6). — P. 1594-1599.
19.Kowluru R. A., Chan P. S. Oxidative stress and diabetic retinopathy // Exp. Diabet. Res. — 2007. — 12 p.
20.Kowluru R. A., Engerman R. L., Case G. L. Retinal glutamate in diabetes and effect of antioxidants // Neurochem. Int. — 2001. — Vol. 38. — P. 385-390.
21.Kowluru R. A., Kanwar M., Kennedy A. Metabolic memory and accumulation of peroxynitrite in retinal capillaries //Exp. Diabet. Res. — 2007. — 7 p.
22.Kowluru R. A., Kowluru V., Xiong Y. Overexpression of mitochondrial superoxide dismutase in mice protects the retina form diabetes-induced oxidative stress // Free Rad. Biol. & Med. — 2006. — Vol. 41 (80). — P. 1191-1196.
23.Lorenzi M., Gerhardinger C. Early cellular and molecular changes induced by diabetes in the retina // Diabetologia. — 2001. — Vol. 44. — P. 791-804.
24.Maasen J. A., Hart L. M., Essen E. Mitochondrial diabetes: Molecular mechanisms and clinical presentation //Diabetes. — 2004. — Vol. 53 (1). — P. S103-S109.
25.Nicholls D. G., Budd S. L. Mitochondria and neuronal survival // Physiolog. Rev. — 2000. — Vol. 80 (10). — P. 315-360.
26.Nishikawa T., Edelstein D., Du X. L. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage // Nature. — 2000. — Vol. 404. — P. 787-790.
27.Obrosova I. G., Drel V. R., Kumagai A. K. Early diabetes-induced biochemical changes in the retina: comparison of rat and mouse models // Diabetologia. — 2006. — Vol. 49. — P. 2525-2533.
28.Obrosova I. G., Abatan O., Larkin D. Taurine replacement attenuates hyperalgesia and abnormal calcium signaling in sensory neurons of STZ-D rats // Am. J. Physiol. Endocrinol. Metab. — 2005. — Vol. 288. — P. E29-E36.
29.Roh Y., Moon C., Kim S. Glutathione depletion induces differential apoptosis in cells of mouse retina, in vivo // Neuroscience Let. — 2007. — Vol.l 417 (3). — P. 266-270.
30.Rosca M. G., Mustata T. G., Kinter M. T. Glication of mi-tochondrial proteins from diabetic rat kidney is associated with excess superoxide formation // Am. J. Physiol. Renal. Physiol. — 2005. — Vol. 289. — P. F420-F430.
31.Stitt A. W., Curtis T. M. Advanced glycation and retinal pathology during diabetes // Farmac. Rep. — 2006. —Vol. 57. — P. 156-168.
32.Tyrberg M., Ponjavic V., Lovestam-Adrian M. Multifocal electroretinography (mfERG) in insulin dependent diabetics with and without clinically apparent retinopathy // Doc. Ophthalmol. — 2005. — Vol. 110. — P. 2-3.
33.Wilkinson-Berka J., Miller A. Update on the treatment of diabetic retinopathy // The Scientific World J. — 2008. — Vol. 8. — P. 98-120.
34.Xia P., Kramer R. M., King G. L. Identification of the mechanisms for the inhibition of Na+, K+-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2 // J. Clin. Invest. — 1995. — Vol. 96. — P. 733-740.